4-hydroxycoumarin Powder

Product Description >>

Physical properties of 4-hydroxycoumarin: white acicular crystal, melting point 210~216 ℃. The industrial product is white or light yellow solid powder with melting point of 210~216 ℃. The industrial product is white or light yellow solid powder with melting point of 210~212 ℃. Slightly soluble in cold water, soluble in hot water, ethanol, ether and other organic solvents. There are many synthetic routes of 4-hydroxycoumarin, and the commonly used production methods in industry are as follows: methyl acetylsalicylate undergoes Clarison condensation under the condition of alkaline catalyst; Acetoacetate reacts with acetylsalicylyl chloride and condenses.It contains chemicals.

Product Function >>

This product is a pharmaceutical organic intermediate used in the production of anticoagulant drugs. The derivatives of this kind of 4-hydroxycoumarin are antagonists of vitamin K and are also oral anticoagulants. In addition, 4-hydroxycoumarin is also an intermediate of some rodenticides, which has great research value in the development of anticancer drugs. 4-hydroxycoumarin is also a spice, and coumarins are widely distributed in the plant kingdom. It is mainly used for the synthesis of antithrombotic drugs and 4-hydroxycoumarin-type anticoagulant rodenticides (warfarin, Dalong, etc.).

Product Application>>

4-Hydroxy Coumarin is a plant derived  oxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes. 4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans. 

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