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Mildronate is a new type of cardioprotective drug, which can inhibit carnitine dependent fatty acid oxidation. Relax vascular smooth muscle, dilate vascular smooth muscle and coronary artery, reduce myocardial oxygen consumption and blood lipid. It can improve myocardial energy metabolism, also known as cellular anti ischemic drugs. Midroxazide can improve the loss of SERCA2 and hexokinase I caused by myocardial infarction, so as to reduce the tissue damage caused by myocardial ischemia and alleviate the hemodynamic dysfunction. It can regulate carnitine dependent fatty acid metabolism under ischemia, making it significantly different from other fatty acid oxidation inhibitors.

76144-81-5

Product name Mildronate
CAS no. 76144-81-5
Molecular Formula C6H14N2O2
Molecular Weight 146.18756
Brand Name Senwayer

Met-88(also known as THP, MET-88 and mildronate) is a novel cardioprotective agent.

Mildronate
Met-88 acts on mitochondria at the cellular level to improve myocardial energy metabolism. In view of these drugs and other anti-myocardial ischemia significantly different, also known as cell anti-ischemic drugs.

Met-88 is a structural analog of carnitine that competes in the inhibition of butyrate betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine and prevent isoproterenol-induced acyl carnitine accumulation. Therefore, the drug has a significant protective effect on the myocardium, resulting in this protective effect at the same time on the hemodynamic parameters had no significant effect, cardiac blood supply and cardiac oxygen consumption was no significant change.


1. Met-88powder is a novel cardioprotective agent.

2.Met-88 acts on mitochondria at the cellular level to improve myocardial energy metabolism. In view of these drugs and other anti-myocardial ischemia significantly different, also known as cell anti-ischemic drugs.

3. Met-88 is a structural analog of carnitine that competes in the inhibition of butyrate betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine and prevent isoproterenol-induced acyl carnitine accumulation.

Therefore, the drug has a significant protective effect on the myocardium, resulting in this protective effect at the same time on the hemodynamic parameters had no significant effect, cardiac blood supply and cardiac oxygen consumption was no significant change.

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Mildronate powder


CAS 76144-81-5

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