The role and efficacy of Paracetamol

3 year ago

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1 min

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Acetaminophen is produced by the metabolism of phenacetin in the body. Its inhibitory effect on prostaglandin synthesis in the central nervous system is similar to that of aspirin, but its inhibitory effect on peripheral prostaglandin synthesis is weak, so it has strong antipyretic and analgesic effects and weak anti-rheumatic effects. No effect on platelet coagulation mechanism. Oral absorption is rapid, complete, and evenly distributed in body fluids. Most of it is metabolized in the liver. The intermediate metabolites are toxic to the liver and are excreted in the form of glucuronic acid conjugates or from the kidneys. The half-life is generally 1-4 hours. For cold and fever, joint pain, neuralgia and migraine, cancer pain and postoperative pain relief. Especially those who are intolerant or allergic to aspirin.

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