Benfotiamine
6 month ago
1.Chemical Properties Lipophilic Characteristics Unlike ordinary water-soluble vitamin B1 (thiamine), benfotiam is highly lipophilic. This allows it to easily penetrate biological membranes such as cell membranes. This property originates from the benzylic and phosphoryl groups in chemical structure, which alter the physical and chemical properties of the molecule, enhancing its solubility and permeability in lipid environments. Stability Benfotine is relatively stable under various environmental conditions. It is more resistant to the acidic environment of gastric acid than ordinary thiamine, making it more stable in the tract, thereby improving its absorption and utilization by the body. Under normal storage conditions, such as cool and dry environments, benfotiamine can maintain its stability for a long time.
2. Uses and Applications Medical Field Prevention and treatment of diabetic complications: Benfotiamine is primarily used in treatment to prevent and alleviate diabetic complications. The high sugar environment in diabetic patients can lead to a series of metabolic disorders, producing excessive advanced glycation end products (s), which can damage nerves, blood vessels, and other tissues. Benfotiamine can activate transketolase, a key enzyme in the pent phosphate pathway, which can reduce the production of AGEs, thereby preventing and treating diabetic complications such as diabetic neuropathy, diabetic retinopathy, and diabetic nephathy. For example, studies have shown that supplementing diabetic patients with benfotiamine can improve nerve conduction velocity and alleviate symptoms of neuropathy such numbness in the hands and feet. Neuroprotection: It also has neuroprotective effects, and in addition to its application in diabetic neuropathy, may have potential therapeutic value for other types of nerve damage or neurodegenerative diseases. For instance, in some experimental models of peripheral nerve injury, benfiamine can promote nerve regeneration and repair and reduce the damage caused by inflammatory reactions to nerves.
Improving cognitive function:
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